About the authorPaul VegasShare the loveHave your say Tottenham legend Ardiles insists title push remains onby Paul Vegasa month agoSend to a friendShare the loveTottenham legend Ossie Ardiles insists a title push remains on.Tottenham are third in the Premier League table after five matches, just two points behind Manchester City but seven adrift of leaders Liverpool.”[It’s been] very positive. I believe that there are two teams to beat – Liverpool and Manchester City – but I think we are one of the teams that can beat them and we are going to try and fight with them all the way,” Ardiles told Sky Sports.”We have a very, very strong squad. That showed last season and in the Champions League as well. “We do have a very strong squad but we have to be a little bit better and I hope we will do it this year.”
Jim Harbaugh was only Michigan’s head coach for one of the program’s three rivalry contests against Ohio State during Ezekiel Elliott’s tenure, but he seems to have made quite an impression on the star running back. Friday, Elliott, who is going through the ESPN car wash today, trashed Harbaugh, telling Paul Finebaum that he’s “tired” of hearing about him. Elliott also called out Harbaugh for talking smack when he hasn’t won a rivalry game. Yikes.“I’m tired of hearing about Coach Harbaugh he needs to get in check with reality” – @EzekielElliott pic.twitter.com/QHElXCl7QV— Paul Finebaum (@finebaum) April 15, 2016more from @EzekielElliott: “you can’t talk smack about a rivalry when you haven’t won a game. You have to win ballgames to talk behind it.”— Paul Finebaum (@finebaum) April 15, 2016Here’s @EzekielElliott‘s full quote about Jim Harbaugh on @finebaum pic.twitter.com/FkeSmMrqZa— John Hayes (@johnP_hayes) April 15, 2016This isn’t exactly a surprise – Elliott has made a living off of trolling Michigan the past few years. But it’s still hilarious, and reminds us that there is no better college football rivalry than Ohio State vs. Michigan.
Teleste will use IBC to highlight its IP over coax solutions.Teleste says it will highlight the advantages of bringing fibre connections to an apartment building (FttB) and utilizing existing coaxial cables for enabling IP delivery to individual apartments, enabling the cost of building fibre level broadband connections to be reduced to one fifth compared to using fibre all the way.Products on show include the DOCSIS Access Hub DAH, which provides a solution for introducing high-speed broadband connections to coaxial cable networks and extend IP network inside apartment buildings and hotels by utilising existing coaxial cable infrastructure.The product includes advanced management tools allowing free capacity allocation, 16 downstream and four upstream channels, QAM64, QAM256, QAM1024 downstream support, QPSK, QAM16, QAM64, QAM256 upstream support, a capacity of 960Mbps downstream and 160 Mbps upstream, remote configuration and management, integrated power supply, amplifier and level 2 switch, Optical interface SFP slot, Ethernet 2xGbE copper and Coax PG11, and encapsulation class IP54Teleste will exhibit at IBC on stand 4.B77
YouTube Red, the Google-owned video site’s paid offering, will launched in multiple markets internationally this year, according to chief business officer Robert Kyncl.Robert KynclKyncl, interviewed by French financial daily Les Echos, said that YouTube’s deal with Univeral Music last month gave it the licenses to distribute the Universal Music catalogue on both a free and pay basis globally.Kyncl said that while YouTube did not have a specific launch date penned in for France, this was a market that was “important for us”.Kyncl’s comments came as YouTube renewed agreements with French copyright collecting agencies SACD and ADAGP, enabling authors represented by the pair to continue to receive remuneration for the exploitation of their intellectual property by YouTube content creators.Google has also been in talks with music rights collecting agency SACEM. Kyncl said that other agreements would follow soon.Kyncl confirmed that YouTube was looking at “a better segmentation” of music and video on YouTube Red, which currently offers the entirety of YouTube content on an ad-free basis for a US$10 monthly fee, which could enable it to better compete with the likes of Spotify in international markets.However, he said that it was “not too late” to launch a product like the existing YouTube Red service internationally in a market that still had plenty of scope to develop.He said that the channel bouquets currently offered as part of YouTube Red in the US would not “for the time being” be offered elsewhere.In terms of original content, Kyncl said that YouTube would continue to focus on investing in talent that had developed a following on the platform. Investing in this talent produced an average increase in audience of about 30%, he said.Kyncl said that “more and more people are becoming video content creators” and compared the evolution of user-generated video to the way that digital photography had unleashed a wave of photographic creativity on the part of general user that had eclipsed professional photography’s share of the market.
In July 2018, the FDA granted an Emergency Use Authorization (EUA) for the DoD’s emergency use of Pathogen-Reduced Leukocyte-Depleted Freeze-Dried Plasma manufactured by the Centre de Transfusion Sanguine des Armées (often referred to as French freeze-dried Plasma). That action reflected the importance that both the DoD and the FDA place on efficiently prioritizing and expediting availability of potentially life-saving biological products that are essential to the urgent care of military personnel, especially those in potential battlefield settings. Granting this authorization supported access to this important product and ensures that it will be available if needed. In July 2018, the FDA approved the atropine autoinjector device as a medical countermeasure for chemical nerve agent exposure. This drug-device product was developed in partnership with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, and was approved six months ahead of the DoD’s product development schedule. In August 2018, following a priority review, the FDA approved the first prophylactic drug for malaria in over 18 years, tafenoquine (Arakoda). This drug was developed in partnership with the U.S. Army Medical Research and Materiel Command. On October 29, 2018, the FDA issued draft guidance to help foster the development and eventual approval of dried plasma products. Since these types of plasma products do not need to be stored frozen and can be reconstituted and administered quickly they can be used by military personnel in remote areas without freezers and other support equipment. Reviewed by James Ives, M.Psych. (Editor)Nov 5 2018Today, the U.S. Food and Drug Administration and the Department of Defense’s (DoD) Office of Health Affairs signed a Memorandum of Understanding regarding medical product development and assessment. This builds upon the work of both agencies to foster and prioritize the efficient development of safe and effective medical products intended to save the lives of American service members.”We’re extremely grateful to the men and women who defend our nation, often at great personal risk and sacrifice. It’s our honor and duty to support our military personnel by ensuring they have access to safe and effective medical products – especially products that meet the unique needs and settings in which soldiers may require medical treatment,” said FDA Commissioner Scott Gottlieb, M.D. “The FDA has already been working closely with the DoD to identify opportunities to expedite availability of medical products, particularly those products used to treat injuries in battlefield settings. For example, as noted below, the Emergency Use Authorization for French freeze-dried plasma that was issued earlier this year. Our close collaboration with DoD has helped us target and more efficiently address DoD’s immediate product priorities and foster development and review of these products in the most streamlined manner possible. We are looking forward to additional partnership opportunities under the MOU.”The MOU formally establishes the framework under which the DoD and the FDA will implement the law passed by Congress in 2017 for enhanced engagements between the DoD and the FDA. Under the terms of this MOU, the FDA will work closely with the DoD to evaluate how best to foster access to safe and effective medical products that serve the military’s medical needs; give the highest level of attention to and expedite review of priority DoD medical products; provide ongoing technical advice to aid in the rapid development and manufacturing of medical products for use by the military; and examine products currently under development to determine opportunities to streamline review and expedite their availability. The 2017 law also expanded the FDA’s authority to authorize emergency uses of medical products to reduce deaths and severity of injuries caused by chemical, biological, radiological or nuclear (CBRN) agents or agents that may cause, or are otherwise associated with, an imminently life-threatening and specific risk to the U.S. military forces and for other purposes.”This MOU furthers the existing partnership between the Department of Defense and the FDA to equip our military with the best and most innovative military medical support possible,” said Terry M. Rauch, Ph.D., M.P.H., M.B.A., Acting Deputy Assistant Secretary of Defense, Health Readiness Policy & Oversight, DOD. “Our servicemen and women risk their lives protecting our country. Today’s MOU reflects the commitment of the DoD and the FDA to ensure timely access to life-saving medical products for U.S. troops and to continue fostering the development of new innovative medical products that can help ensure the operational readiness of American troops. We look forward to continuing to work with the FDA as we analyze and implement measures to provide the best possible medical products and care to all military personnel – on the battlefield, stationed around the world and at home.””Our enhanced collaboration with our DoD partners has been vital to gaining a better understanding of the health needs of those protecting our country,” said Anna Abram, the FDA’s Deputy Commissioner for Policy, Planning, Legislation and Analysis. “Today’s MOU is a key milestone in implementing a robust and enduring pathway that fulfills our commitment to expedite access to safe and effective medical products for our military personnel.”Related StoriesResearchers improve training modules for future surgeons with 3D printingDisrupting ChIP Assay Technology with New AdvancementsSociologist identifies link between decline in stable manufacturing jobs and reduced fertility ratesThe MOU signed today builds upon the approach that the FDA outlined in 2018 to advance the development and availability of medical products to help save the lives of American military personnel in a work plan developed in close collaboration with the DoD. The MOU reflects the agency’s commitment to working to address the medical needs of military personnel, especially by helping to expedite the development and review of medical products that are a priority for the DoD and to aid in the rapid development and manufacturing of safe and effective medical products for use by the U.S. military. Specifically, the MOU sets forth a framework to implement the 2017 law, which included provisions to allow the Secretary of Defense to request, and the FDA to take, specific actions to expedite the development of medical products, and the review of investigational submissions, applications for approval/licensure, and submissions/notifications for clearance for such medical products to diagnose, prevent, treat or mitigate a specific and life-threatening risk to the U.S.As part of the ongoing and frequent collaborations between the FDA and the DoD, additional steps taken over the past several months include: The FDA and the DoD are committed to the ongoing partnership and are confident that today’s MOU will enhance those efforts to better serve the health care needs of American military personnel.The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products. Source:https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm624970.htm
According to the CDC, nearly 40 percent of Americans, 93 million people, are obese, and even more are overweight.For more information and complete survey results, go to: clevelandclinic.org/loveyourheartMethodologyCleveland Clinic’s survey of the general population gathered insights into Americans’ perceptions of heart health and weight. This was an online survey conducted among a national probability sample consisting of 1,002 adults 18 years of age and older, living in the continental United States. The total sample data is nationally representative based on age, gender, ethnicity and educational attainment census data. The online survey was conducted by Research Now and completed between September 20 and September 28, 2018. The margin of error for the total sample at the 95% confidence level is +/- 3.1 percentage points. Source:https://my.clevelandclinic.org/ Reviewed by James Ives, M.Psych. (Editor)Jan 31 2019A Cleveland Clinic survey finds that while most Americans (88 percent) understand that there is a connection between a healthy heart and a healthy weight, most aren’t doing enough – or anything – to combat their own weight issues. The survey found 74 percent are concerned about their weight and 65 percent are worried about getting heart disease due to extra pounds, yet less than half (43 percent) of Americans have tried to make dietary changes to lose weight and 40 percent of those who describe themselves as overweight or obese say they aren’t careful about which foods they eat.Part of the problem may be that Americans aren’t sure what to eat for heart health. Nearly one-in-five (18 percent) believe their diet has nothing to do with their heart health, and a mere 14 percent knew that a Mediterranean diet is healthiest for heart health. What’s more, nearly half of Americans (46 percent) believe using artificial sweeteners is a healthy way to lose weight despite studies showing they don’t promote weight loss.The survey also revealed Americans don’t fully understand the impact excess weight has on their heart and overall health. The overwhelming majority of Americans (87 percent) fail to link obesity to cancer or atrial fibrillation (80 percent). More than half of Americans also don’t know that obesity is linked to high “bad” cholesterol levels (54 percent) or coronary artery disease (57 percent) and two-thirds (64 percent) don’t know it can lead to a stroke.”Most Americans understand abstractly that being overweight or obese is not good for your health, but it seems we are not grasping that the leading causes of death and disability – stroke, cancer, coronary artery disease – are all adversely affected by increased weight,” said Steven Nissen, M.D., chairman of Cardiovascular Medicine at Cleveland Clinic. “We need to do a better job of educating patients and the public about the major consequences of carrying excess weight and the benefits of losing weight. A patient only needs to lose five percent of their body weight to start seeing important health benefits.”Eighty-four percent of Americans say they have tried at least one weight-loss method in the past. About one-third (30 percent) say they typically stick with it between one week and one month. Americans cite dislike of exercise (24 percent) and lack of time (22 percent) as their main barriers to maintaining a healthy weight. Most Americans also believe their metabolism is detrimental to weight loss – 60 percent of women and 46 percent of men say their metabolism is working against them.”Americans may be correct that their metabolism is thwarting their weight loss efforts,” said Dr. Nissen. “Once you’ve been overweight, your body tries to hold on to that excess fat, making it more difficult to lose weight. It’s best to work with your physician to develop a steady long term weight loss plan that will help you keep off the pounds. Quick weight loss programs are not effective.”Related StoriesSmoking triples the risk of death from cardiovascular diseaseImplanted device uses microcurrent to exercise heart muscle in cardiomyopathy patientsWeightlifting is better for the heart than cardioHeart disease is the No. 1 cause of death in the United States and around the world. The survey was conducted as part of Cleveland Clinic’s “Love your Heart” consumer education campaign in celebration of American Heart Month. Cleveland Clinic has been ranked the No. 1 hospital in the country for cardiology and cardiac surgery for 24 years in a row by US News & World Report.Additional survey findings include: All fat is not created equal: When it comes to body shapes, almost half (45%) falsely believe that all types of fat put you at equal risk for heart disease; however, numerous studies have shown that fat stored in the abdomen is the most dangerous. Not feeling the pressure: Most Americans say they are concerned about a family member’s weight (62 percent), or them getting heart disease due to their weight (64%). However, for many, outside pressure to lose the weight doesn’t help. Fifty-seven percent say they don’t need others to tell them to lose weight because they already know they should. Baby Boomers (65 percent) are particularly resistant to others weighing in on their weight. Seeking medical advice: While 44 percent of Americans say they are most likely to turn to their physician for nutrition advice, only a quarter (28 percent) have told their doctor they’d like to lose weight. Even less (22 percent) say they’ve discussed heart health in relation to their weight with their doctor.
Reviewed by James Ives, M.Psych. (Editor)Mar 29 2019A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.The investigators found that in addition to its known ability to block the production of cell growth compounds, the drug DFMO (difluoromethylornithine) acts directly on the bacterium Helicobacter pylori to reduce its virulence. H. pylori infection is the primary cause of gastric cancer.The findings, reported in the March 12 issue of Proceedings of the National Academy of Sciences, support further studies of DFMO for the prevention of stomach cancer, the third leading cause of cancer deaths worldwide.H. pylori infects the stomachs of half of the human population, but only about 1 percent of infected individuals develop stomach cancer. Although it’s possible to treat the infection to prevent stomach cancer, it’s not clear whom to treat. Plus, the bug may be conferring beneficial effects — esophageal reflux diseases, asthma and other allergic disorders occur more frequently in people who are not infected with H. pylori.”H. pylori has co-evolved with humans for at least 60,000 years, probably longer, and attempting to prevent stomach cancer by eliminating the infection with widespread use of antibiotics is not necessarily a good idea,” said Keith Wilson, MD, Thomas F. Frist Sr. Professor of Medicine and professor of Pathology, Microbiology and Immunology.”Our study suggests that it might be possible to reduce the virulence of the bacteria, without having to eliminate it. It’s a speculative and unusual way to think about an infection, but it could be an interesting strategy.”Wilson, who also directs the Vanderbilt Center for Mucosal Inflammation and Cancer, and his team previously linked the production of cell growth compounds called polyamines to the development of stomach cancer in an H. pylori-infected animal model. They demonstrated that treatment of the animals with DFMO, which inhibits an enzyme that is key to the production of polyamines, prevents stomach cancer.Related StoriesCancer killing capability of lesser-known immune cells identifiedSpecial blood test may predict relapse risk for breast cancer patientsStudy reveals link between inflammatory diet and colorectal cancer riskTheir findings are the basis for an ongoing clinical trial of DFMO for stomach cancer prevention in Honduras and Puerto Rico.Patients with pre-malignant lesions in the stomach, as determined by endoscopy, are enrolled in the trial of DFMO and will be studied for disease progression.To further explore how DFMO works, J. Carolina Sierra, PhD, research instructor in Medicine, collected H. pyloribacteria from infected animals that had been treated (or not) with DFMO. Using an in vitro test, she assessed the activity of one of the main H. pylori virulence factors, a protein called CagA. CagA is “injected” into stomach epithelial cells, where it contributes to oncogenic signaling pathways.”What we noticed is that bacterial strains coming from DFMO-treated animals have reduced ability to move this virulence factor into epithelial cells,” Sierra said.The researchers discovered that DFMO treatment — in animals or in vitro — caused mutations in the H. pylori gene that encodes CagY, part of the translocation machinery that injects CagA into cells.They demonstrated that animals infected with H. pylori strains containing mutations in the CagY gene did not develop stomach cancer.This finding, Wilson said, supports using DFMO or other tools to reduce H. pylori virulence for cancer prevention.”This drug (DFMO), which inhibits a very specific enzymatic pathway, also has what some might call ‘off target’ effects: it causes mutations in an H. pylori gene that affects the translocation of CagA,” Wilson said. “The vast majority of gastric cancer is associated with strains that are CagA-positive. If this drug interferes with CagA activity, that’s an added bonus.”The investigators will analyze H. pylori strains isolated from the DFMO trial participants in Honduras and Puerto Rico to determine if there is a similar reduction of bacterial virulence in people.Source: http://news.vumc.org/2019/03/28/cancer-prevention-drug-disables-h-pylori/
In India, 190m people still do not have bank accounts, but the percentage of the population who do have accounts has steadily increased to 80%. In 2017, however, nearly half of all bank accounts in the country had seen no activity over the whole of the previous year. One of the reasons is financial literacy, which remains low both in India and many other developing countries. Many people in India have said they are simply unaware of the different benefits of a bank account, such as overdraft facilities or credit schemes. As many as 62% of the world’s unbanked have received only a primary-level education or less, and in poorer countries the proportion is almost certainly going to be higher. Expecting such people to make complex currency conversions into a new virtual currency is asking a lot. In the first place, there is a need for financial literacy measures and initiatives aimed at motivating them to use the services available. Without this additional support, there is a strong risk that Facebook will boast large numbers of sign-ups but very low rates of transactions from the people who are most in need. Big worldOnly a few days since Facebook’s announcement, libra has faced strong pushback from regulators and policymakers around the world. There is much concern about this proposed shift of power from central banks to a private corporation. But aside from questions about the ethics of data privacy or the creation of a supranational currency, libra faces an important practical question. On the one hand, it is not clear how a model such as libra, where there will presumably be little or no physical presence in many countries, would interact with and adhere to local regulations. On the other hand, if it does conform to the local standards of each country, it is unclear how it will overcome challenges like signing people up and strict documentation requirements. Will it really be able to serve the unbanked better than local providers who are used to the challenges in that specific market already? Entrepreneurs and businesses can either start with a problem and think of the best way to solve it; or they can start with a solution and find the biggest and best problem it might solve. I’m not convinced that libra is a good move in either direction. Facebook either has a huge amount of work to do to adapt its solution to fit the problem better, or it needs to redefine the problem that it is trying to fix. Explore further Citation: Libra: Facebook’s cryptocurrency will not help the billions of people currently excluded from banks (2019, June 28) retrieved 17 July 2019 from https://phys.org/news/2019-06-libra-facebook-cryptocurrency-billions-people.html When Facebook unveiled its new digital currency libra, it explicitly said the initiative was intended to address the problems faced by the world’s unbanked: the 1.7 billion people without a bank account. As well as facing inconvenience, these people generally pay over the odds for financial services like bank transfers or overdrafts. This is a pretty big potential market for Facebook so it’s not surprising that it would target the opportunity. But could libra really transform access to financial services for those who are currently excluded? There are reasons to raise serious doubts. Across the world, the main reasons people give for not holding a bank account is that they don’t have enough money, don’t see the need for an account, find it too expensive, or another family member already has one. Not having the right documentation is also a barrier, as is distrust in the financial system. But the specific barriers to financial inclusion vary significantly by region and are usually a combination of social and economic factors. For instance, while cost is a big barrier in Latin America, lack of documentation is the big issue in Zimbabwe and Philippines. This makes it difficult for any one intervention to be a solution to this huge group of people. Worryingly, the Facebook “white paper” that outlines libra does not really engage with these problems or say how it plans to overcome them. Trust and financial literacyPeople’s trust in institutions can be very important in influencing the extent to which they use their services, as I have found from my own work into microfinance, which I have presented at conferences but is yet to be published in an academic journal. I have found that people are more likely to choose something familiar over something novel. Since libra will be a new currency relying on digital wallets and built on blockchain online ledger technology, it is not short of novelties. Inspiring trust is therefore likely to be a major challenge. And simply signing someone up to an account—be it a bank account or a digital wallet—is only part of the financial inclusion challenge. Credit: NIKS ADS Provided by The Conversation This article is republished from The Conversation under a Creative Commons license. Read the original article. How cryptocurrencies can replace other pay options This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
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